Management of early breast cancer in older women: from screening to treatment
Identifieur interne : 001B30 ( Main/Exploration ); précédent : 001B29; suivant : 001B31Management of early breast cancer in older women: from screening to treatment
Auteurs : Fadwa Elomrani [Maroc] ; Maryem Zine [Maroc] ; Mohamed Afif [Maroc] ; Saad L Nnaz [Maroc] ; Imane Ouziane [Maroc] ; Hind Mrabti [Maroc] ; Hassan Errihani [Maroc]Source :
- Breast Cancer : Targets and Therapy [ 1179-1314 ] ; 2015.
Abstract
Breast cancer is a common condition. It is a leading cause of death among women, and its incidence increases with age. Aging of the population and improvement of the quality of life of elders make it a major public health issue. We reviewed the literature to try to determine the management of breast cancer in older women.
We conducted a narrative review by literature searches using key words “breast cancer”, “elderly and older”, and “women” in Pubmed, Scopus, and Google Scholar. The aim of this review is to summarize the management of early breast cancer in older women by discussing the controversies of screening in older women. Then, we try to define the optimal strategy for these women, either surgery alone or primary endocrine therapy. We also discuss the indications of lymph node dissection, and we evaluate the benefit of adjuvant radiotherapy, chemotherapy, and the anti HER2 treatment for these women.
More than 50% of patients with breast cancer are 65 years or older, and around 30% are more than 70 years old. Most randomized trials did not include older women. Hence, the treatment of breast cancer in older patients is based on the management provided to younger women. Regardless of age, the treatment must aim for the best efficiency. Advanced age in itself should not be a limitation to treatment. There are no standard guidelines set for elderly patients. Surgical treatment for older patients evolved to avoid mastectomy, and conservative mammary surgery was proposed, similar to that used in younger patients. The proportion of elderly patients receiving adjuvant radiotherapy is increasing. The role of adjuvant radiotherapy in older patients with breast cancer was analyzed. Adjuvant chemotherapy is beneficial to women with hormone receptor-negative tumors. In those with hormone receptor-positive tumors, adjuvant chemotherapy in association to trastuzumab is beneficial for HER2-positive tumors, and for women with HER2-negative tumors adjuvant hormonal therapy is a very good option.
Breast cancer is common in older women. This population requires particular and adapted management. It is essential for older patients to be included in new clinical trials for individualized treatment recommendation.
Url:
DOI: 10.2147/BCTT.S87125
PubMed: 26185468
PubMed Central: 4500607
Affiliations:
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xml:lang="fr">Maroc</country><wicri:regionArea>Department of Onco Hematology, Military Hospital Mohamed V, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Afif, Mohamed" sort="Afif, Mohamed" uniqKey="Afif M" first="Mohamed" last="Afif">Mohamed Afif</name><affiliation wicri:level="3"><nlm:aff id="af3-bctt-7-165">Department of Radiotherapy, National Institute of Oncology, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Department of Radiotherapy, National Institute of Oncology, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="L Nnaz, Saad" sort="L Nnaz, Saad" uniqKey="L Nnaz S" first="Saad" last="L Nnaz">Saad L Nnaz</name><affiliation wicri:level="3"><nlm:aff id="af1-bctt-7-165">Department of Medical 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Zine</name><affiliation wicri:level="3"><nlm:aff id="af2-bctt-7-165">Department of Onco Hematology, Military Hospital Mohamed V, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Department of Onco Hematology, Military Hospital Mohamed V, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Afif, Mohamed" sort="Afif, Mohamed" uniqKey="Afif M" first="Mohamed" last="Afif">Mohamed Afif</name><affiliation wicri:level="3"><nlm:aff id="af3-bctt-7-165">Department of Radiotherapy, National Institute of Oncology, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Department of Radiotherapy, National Institute of Oncology, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="L Nnaz, Saad" sort="L Nnaz, Saad" uniqKey="L Nnaz S" first="Saad" last="L Nnaz">Saad L Nnaz</name><affiliation wicri:level="3"><nlm:aff id="af1-bctt-7-165">Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Department of Medical Oncology, National Institute of Oncology, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Ouziane, Imane" sort="Ouziane, Imane" uniqKey="Ouziane I" first="Imane" last="Ouziane">Imane Ouziane</name><affiliation wicri:level="3"><nlm:aff id="af1-bctt-7-165">Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Department of Medical Oncology, National Institute of Oncology, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Mrabti, Hind" sort="Mrabti, Hind" uniqKey="Mrabti H" first="Hind" last="Mrabti">Hind Mrabti</name><affiliation wicri:level="3"><nlm:aff id="af1-bctt-7-165">Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Department of Medical Oncology, National Institute of Oncology, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Errihani, Hassan" sort="Errihani, Hassan" uniqKey="Errihani H" first="Hassan" last="Errihani">Hassan Errihani</name><affiliation wicri:level="3"><nlm:aff id="af1-bctt-7-165">Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Department of Medical Oncology, National Institute of Oncology, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author></analytic><series><title level="j">Breast Cancer : Targets and Therapy</title><idno type="eISSN">1179-1314</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Breast cancer is a common condition. It is a leading cause of death among women, and its incidence increases with age. Aging of the population and improvement of the quality of life of elders make it a major public health issue. We reviewed the literature to try to determine the management of breast cancer in older women.</p></sec><sec><title>Methods</title><p>We conducted a narrative review by literature searches using key words “breast cancer”, “elderly and older”, and “women” in Pubmed, Scopus, and Google Scholar. The aim of this review is to summarize the management of early breast cancer in older women by discussing the controversies of screening in older women. Then, we try to define the optimal strategy for these women, either surgery alone or primary endocrine therapy. We also discuss the indications of lymph node dissection, and we evaluate the benefit of adjuvant radiotherapy, chemotherapy, and the anti HER2 treatment for these women.</p></sec><sec><title>Results</title><p>More than 50% of patients with breast cancer are 65 years or older, and around 30% are more than 70 years old. Most randomized trials did not include older women. Hence, the treatment of breast cancer in older patients is based on the management provided to younger women. Regardless of age, the treatment must aim for the best efficiency. Advanced age in itself should not be a limitation to treatment. There are no standard guidelines set for elderly patients. Surgical treatment for older patients evolved to avoid mastectomy, and conservative mammary surgery was proposed, similar to that used in younger patients. The proportion of elderly patients receiving adjuvant radiotherapy is increasing. The role of adjuvant radiotherapy in older patients with breast cancer was analyzed. Adjuvant chemotherapy is beneficial to women with hormone receptor-negative tumors. In those with hormone receptor-positive tumors, adjuvant chemotherapy in association to trastuzumab is beneficial for HER2-positive tumors, and for women with HER2-negative tumors adjuvant hormonal therapy is a very good option.</p></sec><sec><title>Conclusion</title><p>Breast cancer is common in older women. This population requires particular and adapted management. It is essential for older patients to be included in new clinical trials for individualized treatment recommendation.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Binder Foucard, F" uniqKey="Binder Foucard F">F Binder-Foucard</name></author><author><name sortKey="Bossard, N" uniqKey="Bossard N">N Bossard</name></author><author><name sortKey="Delafosse, P" uniqKey="Delafosse P">P Delafosse</name></author><author><name sortKey="Belot, A" uniqKey="Belot A">A Belot</name></author><author><name sortKey="Woronoff, As" uniqKey="Woronoff A">AS Woronoff</name></author><author><name sortKey="Remontet, L" uniqKey="Remontet L">L Remontet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yancik, R" uniqKey="Yancik R">R Yancik</name></author><author><name sortKey="Ries, La" uniqKey="Ries L">LA Ries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Clegg, Lx" uniqKey="Clegg L">LX Clegg</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ries, Lag" uniqKey="Ries L">LAG Ries</name></author><author><name sortKey="Eisner, Mp" uniqKey="Eisner M">MP Eisner</name></author><author><name sortKey="Kosary, Cl" uniqKey="Kosary C">CL Kosary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walter, Lc" uniqKey="Walter L">LC Walter</name></author><author><name sortKey="Schonberg, Ma" uniqKey="Schonberg M">MA Schonberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marmot, Mg" uniqKey="Marmot M">MG Marmot</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author><author><name sortKey="Cameron, Da" uniqKey="Cameron D">DA Cameron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diab, Sg" uniqKey="Diab S">SG Diab</name></author><author><name sortKey="Elledge, Rm" uniqKey="Elledge R">RM Elledge</name></author><author><name sortKey="Clark, Gm" uniqKey="Clark G">GM Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, Jw" uniqKey="Berg J">JW Berg</name></author><author><name sortKey="Hutter, Rv" uniqKey="Hutter R">RV Hutter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monfardini, S" uniqKey="Monfardini S">S Monfardini</name></author><author><name sortKey="Ferrucci, L" uniqKey="Ferrucci L">L Ferrucci</name></author><author><name sortKey="Fratino, L" uniqKey="Fratino L">L Fratino</name></author><author><name sortKey="Del Lungo, I" uniqKey="Del Lungo I">I Del Lungo</name></author><author><name sortKey="Serraino, D" uniqKey="Serraino D">D Serraino</name></author><author><name sortKey="Zagonel, V" uniqKey="Zagonel V">V Zagonel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Audisio, Ra" uniqKey="Audisio R">RA Audisio</name></author><author><name sortKey="Wyld, L" uniqKey="Wyld L">L Wyld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiderlen, M" uniqKey="Kiderlen M">M Kiderlen</name></author><author><name sortKey="Bastiaannet, E" uniqKey="Bastiaannet E">E Bastiaannet</name></author><author><name sortKey="Walsh, Pm" uniqKey="Walsh P">PM Walsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robertson, Jf" uniqKey="Robertson J">JF Robertson</name></author><author><name sortKey="Todd, Jh" uniqKey="Todd J">JH Todd</name></author><author><name sortKey="Ellis, Io" uniqKey="Ellis I">IO Ellis</name></author><author><name sortKey="Elston, Cw" uniqKey="Elston C">CW Elston</name></author><author><name sortKey="Blamey, Rw" uniqKey="Blamey R">RW Blamey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gazet, Jc" uniqKey="Gazet J">JC Gazet</name></author><author><name sortKey="Ford, Ht" uniqKey="Ford H">HT Ford</name></author><author><name sortKey="Coombes, Rc" uniqKey="Coombes R">RC Coombes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fentiman, Is" uniqKey="Fentiman I">IS Fentiman</name></author><author><name sortKey="Christiaens, Mr" uniqKey="Christiaens M">MR Christiaens</name></author><author><name sortKey="Paridaens, R" uniqKey="Paridaens R">R Paridaens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mustacchi, G" uniqKey="Mustacchi G">G Mustacchi</name></author><author><name sortKey="Ceccherini, R" uniqKey="Ceccherini R">R Ceccherini</name></author><author><name sortKey="Milani, S" uniqKey="Milani S">S Milani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bates, T" uniqKey="Bates T">T Bates</name></author><author><name sortKey="Riley, Dl" uniqKey="Riley D">DL Riley</name></author><author><name sortKey="Houghton, J" uniqKey="Houghton J">J Houghton</name></author><author><name sortKey="Fallowfield, L" uniqKey="Fallowfield L">L Fallowfield</name></author><author><name sortKey="Baum, M" uniqKey="Baum M">M Baum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hind, D" uniqKey="Hind D">D Hind</name></author><author><name sortKey="Wyld, L" uniqKey="Wyld L">L Wyld</name></author><author><name sortKey="Reed, M" uniqKey="Reed M">M Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biganzoli, L" uniqKey="Biganzoli L">L Biganzoli</name></author><author><name sortKey="Wildiers, H" uniqKey="Wildiers H">H Wildiers</name></author><author><name sortKey="Oakman, C" uniqKey="Oakman C">C Oakman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willsher, Pc" uniqKey="Willsher P">PC Willsher</name></author><author><name sortKey="Robertson, Jfr" uniqKey="Robertson J">JFR Robertson</name></author><author><name sortKey="Jackson, L" uniqKey="Jackson L">L Jackson</name></author><author><name sortKey="Al Hilaly, M" uniqKey="Al Hilaly M">M Al-Hilaly</name></author><author><name sortKey="Blarney, Rw" uniqKey="Blarney R">RW Blarney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fennessey, M" uniqKey="Fennessey M">M Fennessey</name></author><author><name sortKey="Bates, T" uniqKey="Bates T">T Bates</name></author><author><name sortKey="Mcrae, K" uniqKey="Mcrae K">K McRae</name></author><author><name sortKey="Riley, D" uniqKey="Riley D">D Riley</name></author><author><name sortKey="Houghton, J" uniqKey="Houghton J">J Houghton</name></author><author><name sortKey="Baum, M" uniqKey="Baum M">M Baum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Capasso, I" uniqKey="Capasso I">I Capasso</name></author><author><name sortKey="Nuzzo, F" uniqKey="Nuzzo F">F Nuzzo</name></author><author><name sortKey="Labonia, V" uniqKey="Labonia V">V Labonia</name></author><author><name sortKey="Landi, G" uniqKey="Landi G">G Landi</name></author><author><name sortKey="Rossi, E" uniqKey="Rossi E">E Rossi</name></author><author><name sortKey="De Matteis, A" uniqKey="De Matteis A">A De Matteis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, B" uniqKey="Fisher B">B Fisher</name></author><author><name sortKey="Bauer, M" uniqKey="Bauer M">M Bauer</name></author><author><name sortKey="Wickerham, D" uniqKey="Wickerham D">D Wickerham</name></author><author><name sortKey="Redmond, Ck" uniqKey="Redmond C">CK Redmond</name></author><author><name sortKey="Fisher, Er" uniqKey="Fisher E">ER Fisher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martelli, G" uniqKey="Martelli G">G Martelli</name></author><author><name sortKey="Miceli, R" uniqKey="Miceli R">R Miceli</name></author><author><name sortKey="Daidone, Mg" uniqKey="Daidone M">MG Daidone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armando, E" uniqKey="Armando E">E Armando</name></author><author><name sortKey="Giuliano, Md" uniqKey="Giuliano M">MD Giuliano</name></author><author><name sortKey="Kelly, K" uniqKey="Kelly K">K Kelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrek, Ja" uniqKey="Petrek J">JA Petrek</name></author><author><name sortKey="Heelan, Mc" uniqKey="Heelan M">MC Heelan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, Sj" uniqKey="Hall S">SJ Hall</name></author><author><name sortKey="Brown, Se" uniqKey="Brown S">SE Brown</name></author><author><name sortKey="Porter, Grj" uniqKey="Porter G">GRJ Porter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Syed, A" uniqKey="Syed A">A Syed</name></author><author><name sortKey="Garbos, M" uniqKey="Garbos M">M Garbos</name></author><author><name sortKey="Patel, A" uniqKey="Patel A">A Patel</name></author><author><name sortKey="Bradpiece, H" uniqKey="Bradpiece H">H Bradpiece</name></author><author><name sortKey="Stephanie, J" uniqKey="Stephanie J">J Stephanie</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Biganzoli, L" uniqKey="Biganzoli L">L Biganzoli</name></author><author><name sortKey="Goldhirsh, A" uniqKey="Goldhirsh A">A Goldhirsh</name></author><author><name sortKey="Straehle, C" uniqKey="Straehle C">C Straehle</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Giordano, Sh" uniqKey="Giordano S">SH Giordano</name></author><author><name sortKey="Duan, Z" uniqKey="Duan Z">Z Duan</name></author><author><name sortKey="Kuo, Yf" uniqKey="Kuo Y">YF Kuo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elkin, Eb" uniqKey="Elkin E">EB Elkin</name></author><author><name sortKey="Hurria, A" uniqKey="Hurria A">A Hurria</name></author><author><name sortKey="Mitra, N" uniqKey="Mitra N">N Mitra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muss, Hb" uniqKey="Muss H">HB Muss</name></author><author><name sortKey="Berry, D" uniqKey="Berry D">D Berry</name></author><author><name sortKey="Constance, T" uniqKey="Constance T">T Constance</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jager, A" uniqKey="Jager A">A Jager</name></author><author><name sortKey="Verweij, J" uniqKey="Verweij J">J Verweij</name></author><author><name sortKey="Sleijfer, S" uniqKey="Sleijfer S">S Sleijfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kunkler, I" uniqKey="Kunkler I">I Kunkler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes, Ks" uniqKey="Hughes K">KS Hughes</name></author><author><name sortKey="Schnaper, La" uniqKey="Schnaper L">LA Schnaper</name></author><author><name sortKey="Bellon, Jr" uniqKey="Bellon J">JR Bellon</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Castiglione, M" uniqKey="Castiglione M">M Castiglione</name></author><author><name sortKey="Gelber, Rd" uniqKey="Gelber R">RD Gelber</name></author><author><name sortKey="Goldhirsh, A" uniqKey="Goldhirsh A">A Goldhirsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cummings, Fj" uniqKey="Cummings F">FJ Cummings</name></author><author><name sortKey="Gray, Dc" uniqKey="Gray D">DC Gray</name></author><author><name sortKey="Tormey, Te" uniqKey="Tormey T">TE Tormey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mouridsen, Ht" uniqKey="Mouridsen H">HT Mouridsen</name></author><author><name sortKey="Andersen, Ap" uniqKey="Andersen A">AP Andersen</name></author><author><name sortKey="Brincker, H" uniqKey="Brincker H">H Brincker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crivellari, D" uniqKey="Crivellari D">D Crivellari</name></author><author><name sortKey="Price, K" uniqKey="Price K">K Price</name></author><author><name sortKey="Richard, D" uniqKey="Richard D">D Richard</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Baum, M" uniqKey="Baum M">M Baum</name></author><author><name sortKey="Buzdar, A" uniqKey="Buzdar A">A Buzdar</name></author><author><name sortKey="Cuzick, J" uniqKey="Cuzick J">J Cuzick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunello, A" uniqKey="Brunello A">A Brunello</name></author><author><name sortKey="Monfardini, S" uniqKey="Monfardini S">S Monfardini</name></author><author><name sortKey="Crivellari, D" uniqKey="Crivellari D">D Crivellari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paton, Ve" uniqKey="Paton V">VE Paton</name></author><author><name sortKey="Klein, P" uniqKey="Klein P">P Klein</name></author><author><name sortKey="Lieberman, G" uniqKey="Lieberman G">G Lieberman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fyfe, Ga" uniqKey="Fyfe G">GA Fyfe</name></author><author><name sortKey="Mass, R" uniqKey="Mass R">R Mass</name></author><author><name sortKey="Murphy, M" uniqKey="Murphy M">M Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serrano, C" uniqKey="Serrano C">C Serrano</name></author><author><name sortKey="Cortes, J" uniqKey="Cortes J">J Cortés</name></author><author><name sortKey="De Mattos Arruda, L" uniqKey="De Mattos Arruda L">L De Mattos-Arruda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chavez Macgregor, M" uniqKey="Chavez Macgregor M">M Chavez-MacGregor</name></author><author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name></author><author><name sortKey="Buchholz, Ta" uniqKey="Buchholz T">TA Buchholz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Maroc</li></country><region><li>Rabat-Salé-Kénitra</li></region><settlement><li>Rabat</li></settlement></list><tree><country name="Maroc"><region name="Rabat-Salé-Kénitra"><name sortKey="Elomrani, Fadwa" sort="Elomrani, Fadwa" uniqKey="Elomrani F" first="Fadwa" last="Elomrani">Fadwa Elomrani</name></region><name sortKey="Afif, Mohamed" sort="Afif, Mohamed" uniqKey="Afif M" first="Mohamed" last="Afif">Mohamed Afif</name><name sortKey="Errihani, Hassan" sort="Errihani, Hassan" uniqKey="Errihani H" first="Hassan" last="Errihani">Hassan Errihani</name><name sortKey="L Nnaz, Saad" sort="L Nnaz, Saad" uniqKey="L Nnaz S" first="Saad" last="L Nnaz">Saad L Nnaz</name><name sortKey="Mrabti, Hind" sort="Mrabti, Hind" uniqKey="Mrabti H" first="Hind" last="Mrabti">Hind Mrabti</name><name sortKey="Ouziane, Imane" sort="Ouziane, Imane" uniqKey="Ouziane I" first="Imane" last="Ouziane">Imane Ouziane</name><name sortKey="Zine, Maryem" sort="Zine, Maryem" uniqKey="Zine M" first="Maryem" last="Zine">Maryem Zine</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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